(S)-4-Hydroxymethyl ambrisentan
CAS: 1106685-66-8
Ref. 3D-GUB68566
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Informação sobre produto
(S)-4-Hydroxymethyl ambrisentan is a selective endothelin receptor antagonist that has been shown to inhibit cell proliferation in human liver and muscle cells. It also inhibits the metabolism of bosentan, a drug used for the treatment of pulmonary hypertension, through inhibition of cytochrome P450 enzymes. (S)-4-Hydroxymethyl ambrisentan has been shown to be safe and effective as an anti-cancer agent in animal studies. In addition, it has been shown to protect against renal transplantation rejection. The pharmacokinetic properties of (S)-4-hydroxymethyl ambrisentan are similar to those of sildenafil, with a half-life of 2 hours and peak concentration at 3 hours after administration. The drug does not interact with other drugs, but there is potential for interactions with drugs that are substrates for CYP3A4 and CYP2D6 enzymes.
Propriedades químicas
Consulta técnica sobre: 3D-GUB68566 (S)-4-Hydroxymethyl ambrisentan
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