Informação sobre produto
NNC-0640 is a novel incretin hormone receptor binding agent. It has been shown to be an allosteric modulator of the GLP-1R, and it has been shown to promote insulin secretion in diabetic patients. NNC-0640 binds to the GLP-1R and enhances the affinity of the receptor for its ligand, GLP-1. Binding of this drug to the GLP-1R leads to increased activation of adenylyl cyclase (AC), which results in increased intracellular levels of cyclic AMP (cAMP). This increase in cAMP activates protein kinase A (PKA) by phosphorylation, which then initiates signaling pathways that lead to insulin secretion. The allosteric modulation of NNC-0640 is thought to be due to a conformational change in the receptor caused by binding with this drug.
NNC-0640 is a novel incretin hormone receptor binding agent
Propriedades químicas
Consulta técnica sobre: 3D-HMA98698 NNC-0640
Se desejar solicitar um orçamento ou fazer uma encomenda, por favor, adicione os produtos ao seu carrinho e depois solicite um orçamento ou encomenda a partir do carrinho. É mais rápido, mais barato e poderá beneficiar-se dos descontos e outras vantagens disponíveis.
