4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide

CAS: 932737-65-0

Ref. 3D-HMB73765

Informação sobre produto

• Nome: 4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide

Descrição

4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide is an allosteric modulator of metabotropic glutamate receptors. It has been shown to inhibit lipid biosynthesis in cells (e.g., COS cells) and has been used as a radiation sensitizer for low energy photon therapy for cancer treatment. 4FMTAB binds to the extracellular signal domain of the metabotropic glutamate receptor, which is a G protein coupled receptor. This binding inhibits the signal detection process, leading to a decrease in intracellular cAMP levels and subsequent inhibition of protein synthesis. 4FMTAB also inhibits translation by binding to the ribosome and inhibiting peptide bond formation between amino acids.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 371.43 g/mol
• Fórmula: C₁₈H₁₈FN₅OS
• Pureza: Min. 95%