![4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide](https://static.cymitquimica.com/products/3D/img/HMB73765.png "Clique para ampliar")
4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide
CAS: 932737-65-0
Ref. 3D-HMB73765
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Informação sobre produto
4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide is an allosteric modulator of metabotropic glutamate receptors. It has been shown to inhibit lipid biosynthesis in cells (e.g., COS cells) and has been used as a radiation sensitizer for low energy photon therapy for cancer treatment. 4FMTAB binds to the extracellular signal domain of the metabotropic glutamate receptor, which is a G protein coupled receptor. This binding inhibits the signal detection process, leading to a decrease in intracellular cAMP levels and subsequent inhibition of protein synthesis. 4FMTAB also inhibits translation by binding to the ribosome and inhibiting peptide bond formation between amino acids.
Propriedades químicas
Consulta técnica sobre: 3D-HMB73765 4-Fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]benzamide
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