5-Chloro-8-nitroisoquinoline

CAS: 58142-95-3

Ref. 3D-ICA14295

Informação sobre produto

• Nome: 5-Chloro-8-nitroisoquinoline
• Marca: Biosynth
• Descrição: 5-Chloro-8-nitroisoquinoline is a cytotoxic agent that belongs to the class of pyridopyrimidines. It is an amidation product of 8-nitroisoquinoline and 5-chloroacetaldehyde, which is prepared by condensation of nitrostyrene with acetone. 5-Chloro-8-nitroisoquinoline has anticancer activity against human cancer cells in vitro and in vivo. The mechanism of action is multidrug resistance, mediated by overexpression of P glycoprotein. This drug also inhibits the reductive activation of hypoxia inducible factor (HIF) alpha, which leads to its cytotoxicity.

Propriedades químicas

• Peso molecular: 208.6 g/mol
• Fórmula: C₉H₅ClN₂O₂
• Pureza: Min. 95%