Informação sobre produto
VU0071063 is a small molecule that inhibits the mitochondrial membrane potential, which prevents hyperinsulinism. It has been shown to have a pharmacokinetic property that makes it suitable for oral administration. VU0071063 is metabolized in the liver, but penetrates the blood-brain barrier and reaches high concentrations in the pancreas. The compound has a low toxicity profile and shows no appreciable cardiotoxicity. VU0071063 inhibits both subunits of ATP synthase, preventing movement of potassium ions across the mitochondrial membrane and increasing intracellular calcium ion levels. This leads to impaired insulin secretion by pancreatic β-cells, as well as decreased ATP production by other cells.
Propriedades químicas
Consulta técnica sobre: 3D-INA41538 VU0071063
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