Informação sobre produto
PF-5190457 is a human liver-specific inhibitor of the enzyme indoleamine 2,3-dioxygenase (IDO), an enzyme that catalyzes the conversion of tryptophan to N-formylkynurenine. PF-5190457 has been shown in clinical studies to be safe and effective for the treatment of inflammatory diseases such as rheumatoid arthritis. This drug also inhibits IL-10 production in humans and has anti-inflammatory effects. PF-5190457 is orally administered and reaches high concentrations in the liver, which leads to a matrix effect. The drug is metabolized by the oxidation of its nitrogen atoms, leading to its excretion through urine or bile. PF-5190457 binds to cytosolic proteins and may have potential as a therapeutic agent for obesity, since it decreases body mass index in humans.
Propriedades químicas
Consulta técnica sobre: 3D-JDC78279 PF-5190457
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