4-Hydroxy toremifene
CAS: 110503-62-3
Ref. 3D-KEA50362
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Informação sobre produto
- (Z)-4-(4-Chloro-1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)phenol
- (Z)-4-Hydroxytoremifene
- 4-[(1Z)-4-Chloro-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
- 4-[(1Z)-4-chloro-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
- Phenol, 4-(4-chloro-1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-, (Z)-
- Phenol, 4-[(1Z)-4-chloro-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
- Phenol, 4-[(1Z)-4-chloro-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-
Toremifene is an antiestrogen that binds to the estrogen receptor and blocks the interaction of estrogens with this receptor. It also inhibits epidermal growth factor, which stimulates cell proliferation. Toremifene is a chemotherapeutic agent that has been shown to inhibit oxidative DNA damage in human endometrial cells in vitro. Kinetic data showed that response element-mediated transcriptional activation was inhibited by toremifene at concentrations greater than 0.1 μM. A multicenter phase II trial showed that toremifene was effective for treating metastatic breast cancer. Toremifene can also be used for the treatment of estrogen-dependent cancers, such as prostate cancer and ovarian cancer, and may have other uses, such as in the treatment of metabolic disorders and liver diseases.
Propriedades químicas
Consulta técnica sobre: 3D-KEA50362 4-Hydroxy toremifene
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