2,3,5-Tri-O-benzoyl-b-D-ribofuranosyl azide
CAS: 7408-41-5
Ref. 3D-MT06420
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Informação sobre produto
- (2R,3R,4R,5R)-2-Azido-5-[(benzoyloxy)methyl]tetrahydrofuran-3,4-diyl dibenzoate (non-preferred name)
- (2R,3R,4R,5R)-2-azido-5-{[(phenylcarbonyl)oxy]methyl}tetrahydrofuran-3,4-diyl dibenzoate (non-preferred name)
- 2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl azide
2,3,5-Tri-O-benzoyl-b-D-ribofuranosyl azide (2,3,5-TRBA) is an antiviral agent that inhibits the synthesis of viral nucleic acid by targeting a glycosylation step in the synthesis of herpes simplex virus type 1 (HSV1). 2,3,5-TRBA has significant antiviral activity against HSV1 and other herpes viruses. This compound is also active against influenza A virus and vaccinia virus. 2,3,5-TRBA inhibits the enzyme triosephosphate isomerase (TPI), which catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde 3-phosphate. Inhibition of TPI leads to decreased glucose production in cells infected with herpes viruses. The acetonitrile used as a solvent in this reaction can be replaced by pyridine or DMF. The sulfonate group
Propriedades químicas
Consulta técnica sobre: 3D-MT06420 2,3,5-Tri-O-benzoyl-b-D-ribofuranosyl azide
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