Tri-b-GalNAc-C12-alkyne
Ref. 3D-MT184241
1mg | 485,00 € | ||
5mg | 1.334,00 € |
Informação sobre produto
- Tris-β-GalNAc-C12-alkyneTreble GalNAc AlkyneTriantennary β-GalNAc alkynetri-GalNAc beta alkynetris-GalNAc-beta-C12-alkyneAlkyne -C12-tris-beta-GALNAC
Tri-b-GalNAc-C12-alkyne, also known as trebler GalNAc alkyne, is a multivalent N-acetylgalactosamine (GalNAc) compound with high-affinity to bind to the asialoglycoprotein receptor (ASGPR) found on the surface of hepatocytes in the liver. This trivalent GalNAc derivative contains a C12 alkyne linker and has been extensively studied for its potential in targeted delivery of siRNA conjugates to liver tissue. The multivalent presentation of GalNAc moieties significantly enhances the binding avidity to ASGPR making it an attractive ligand for liver-specific targeting. Researchers have reported successful conjugation of tri-b-GalNAc-C12-alkyne to various therapeutic payloads, such as small interfering RNAs (siRNAs), to facilitate their selective uptake by hepatocytes and enable targeted gene silencing in the liver.
Propriedades químicas
Consulta técnica sobre: 3D-MT184241 Tri-b-GalNAc-C12-alkyne
Se desejar solicitar um orçamento ou fazer uma encomenda, por favor, adicione os produtos ao seu carrinho e depois solicite um orçamento ou encomenda a partir do carrinho. É mais rápido, mais barato e poderá beneficiar-se dos descontos e outras vantagens disponíveis.