Informação sobre produto
- Uridine, 5-bromo-2',3'-dideoxy-
- 5-bromo-1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
- 5-bromo-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
5-Bromo-2',3'-dideoxyuridine is a nucleoside analogue that is used as a chemotherapeutic drug against various types of cancer. It has been shown to have anti-tumour activity by interfering with the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). 5-Bromo-2',3'-dideoxyuridine binds to the sugar ring in DNA and inhibits the enzyme DNA polymerase from synthesizing DNA. This drug also stabilizes conformations of the molecule, which are responsible for its pharmacological effects.
5-Bromo-2',3'-dideoxyuridine can be found in two different crystal structures, monoclinic and tetragonal. The monoclinic form is stabilized by hydrogen bonds between the puckers in the sugar ring and hydrogen bonds to neighboring molecules. This form is more soluble than the tetragonal form,
Propriedades químicas
Consulta técnica sobre: 3D-NB02934 5-Bromo-2',3'-dideoxyuridine
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