2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine
CAS: 135598-68-4
Ref. 3D-NC29827
| Tamanho indefinido | A consultar |
Informação sobre produto
2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine is an analog of the natural substrate for DNA cytosine methyltransferase, 5-methylcytosine. 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine inhibits the enzyme activity of DNA methyltransferase and blocks cell proliferation. It has been shown to be a potent antitumor agent in experimental models and may serve as a potential biomarker for cancer treatment. The drug is an oral prodrug that is activated by deamination in the liver and kidneys to release the active form, 5'-Azacytidine monophosphate (5'AZA). This metabolite then inhibits DNA methylation by binding to DNA cytosine methyltransferase, resulting in a loss of function of this enzyme.
Propriedades químicas
Consulta técnica sobre: 3D-NC29827 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine
Se desejar solicitar um orçamento ou fazer uma encomenda, por favor, adicione os produtos ao seu carrinho e depois solicite um orçamento ou encomenda a partir do carrinho. É mais rápido, mais barato e poderá beneficiar-se dos descontos e outras vantagens disponíveis.
