2',3'-Dideoxycytidine 5'-monophosphate

CAS: 104086-76-2

Ref. 3D-ND170662

Informação sobre produto

• Nome: 2',3'-Dideoxycytidine 5'-monophosphate
• Sinónimos: Zalcitabine monophosphate2',3'-Dideoxy-5'-cytidylic acid, 2',3'-Dideoxy-5'-Cytidylicaci, 2',3'-Dideoxycytidine monophosphate, 2′,3′-Dideoxy-5′-cytidylic acid, 2′,3′-Dideoxycytidine 5′-monophosphate, 2′,3′-Dideoxycytidine monophosphate, 5'-Cytidylic acid, 2',3'-dideoxy-, 5′-Cytidylic acid, 2′,3′-dideoxy-, Cytidine-5'-Monophosphate Monohydrate, Zalcitabine monophosphate, [(2S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate

Descrição

Dideoxycytidine 5'-monophosphate (DDCMP) is a molecule that inhibits HIV infection by inhibiting the synthesis of DNA. It binds to the dna template strand, preventing the addition of new nucleotides and thus blocking the progression of HIV infection. DDCMP has been shown to be potent in vitro and in vivo in clinical studies. In cell culture, DDCMP has been shown to inhibit DNA duplexes, leading to a decrease in lymphocytic leukemia cells activated by T-cell receptor stimulation. Structural biology studies have revealed that DDCMP inhibits HIV-1 reverse transcriptase through binding at the M2 subunit of the enzyme's active site.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 291.2 g/mol
• Fórmula: C₉H₁₄N₃O₆P
• Pureza: Min. 95%
• Cor/forma: Powder
• InChI: InChI=1S/C9H14N3O6P/c10-7-3-4-12(9(13)11-7)8-2-1-6(18-8)5-17-19(14,15)16/h3-4,6,8H,1-2,5H2,(H2,10,11,13)(H2,14,15,16)/t6-,8+/m0/s1
• Chave InChI: InChIKey=RAJMXAZJKUGYGW-POYBYMJQSA-N
• SMILES: Nc1ccn([C@H]2CC[C@@H](COP(=O)(O)O)O2)c(=O)n1