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N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine
CAS: 163706-58-9
Ref. 3D-NGA70658
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Informação sobre produto
- N6-(2-methylthioethyl)-2-(3,3,3-trifluoropropylthio)adenosine
- N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine
The synthetic route to N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine (MTEA), a nucleophilic nitro compound, begins with the chlorinating of methyl 2-hydroxyethyl thiocyanate with phosphorus oxychloride in an organic solvent. The chloroform is then removed by liquid chromatography and MTEA is obtained as a colorless liquid. It has been used for the industrial preparation of cangrelor, a pharmaceutical agent. Impurities such as 2-(methylsulfinyl)ethanol and 3,3,3-trifluoro-1-propanol are identified by using liquid chromatography.
The reaction time required for this process is 1 hour at 100°C.
Propriedades químicas
Consulta técnica sobre: 3D-NGA70658 N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine
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