Informação sobre produto
- 2-Anilinoadenosine2-Phenylamino-D-adenosine
- 2-(Phenylamino)adenosine
- 9-pentofuranosyl-N~2~-phenyl-9H-purine-2,6-diamine
- Adenosine, 2-(phenylamino)-
- Cv-1808
- Lsu 165
- N2-Phenyl-2,6-diaminonebularine
2-Phenylaminoadenosine (2-PA) is a potent and selective inhibitor of the P2Y receptor. 2-PA has been shown to reduce myocardial infarct size in vivo in mice, which may be due to its ability to inhibit the release of dopamine from the brain. In addition, 2-PA binds to LPS receptors on endothelial cells, reducing the production of proinflammatory cytokines and preventing platelet aggregation. 2-PA also inhibits the activation of toll-like receptor 4 (TLR4) in human monocytes, leading to reduced expression of proinflammatory cytokines and increased expression of anti-inflammatory cytokines.
2-PA is an agonist that binds with high affinity to P2Y receptors on erythrocytes. This binding results in decreased adenosine triphosphate (ATP) production by adenosine deaminase, which leads to decreased intracellular calcium levels and inhibition of neutroph
Propriedades químicas
Consulta técnica sobre: 3D-NP07291 2-Phenylaminoadenosine
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