Timosaponin A-III

CAS: 41059-79-4

Ref. 3D-OT10477

Informação sobre produto

• Nome: Timosaponin A-III
• Sinónimos: Anemarsaponin A3Filiferin B(3b,5b,25S)-Spirostan-3-yl 2-O-b-D-glucopyranosyl-b-D-galactopyranoside, Timosaponine A III, Timosaponin A III, (3β,5β,25S)-Spirostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside, β-D-Galactopyranoside, (3β,5β,25S)-spirostan-3-yl 2-O-β-D-glucopyranosyl-, Filiferin B

Descrição

Timosaponin A-III is a saponin compound that is found in the roots of Timosaponis chinensis. It has been shown to have anti-cancer effects in vitro, as well as anti-inflammatory and antioxidant properties. In particular, it inhibits the function of P-glycoprotein (Pgp) and prevents its translocation from the Golgi apparatus to the cell membrane. This decreases the efflux of anticancer drugs from cells. Timosaponin A-III also has an effect on cyclin D2, which is a protein that regulates cell cycle progression. The hypoglycemic effect seen in animal studies may be due to its synergic effect with insulin and preparative high performance liquid chromatography (HPLC). Timosaponin A-III also has significant cytotoxicity against HL-60 cells, which are a type of leukemia cells. It binds to response elements on DNA and activates transcription factors such as NF-κB and AP1,

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 740.92 g/mol
• Fórmula: C₃₉H₆₄O₁₃
• Pureza: Min. 98 Area-%
• Cor/forma: Off-White Powder