BQ-123 Sodium Salt

CAS: 136553-81-6

Ref. 3D-PED-3512-PI

Informação sobre produto

• Nome: BQ-123 Sodium Salt
• Sinónimos: cyclo(D-asp-pro-D-val-leu-D-trp), Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu), D-alpha-aspartyl-L-prolyl-D-valyl-N-[(2R)-1-(1H-indol-3-yl)-3-oxopropan-2-yl]-4-methylidene-L-norvalinamide, cyclo(D-alpha-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl), Cyclo(Alpha-Aspartylprolylvalylleucyltryptophyl), Bq-123 Sodium Salt

Descrição

BQ-123 is a cyclic peptide that blocks the endothelin-A receptor. It has been shown to be an effective treatment for pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. BQ-123 binds to the endothelin-A receptor, which is located on the surface of cells in many tissues throughout the body. When bound, it inhibits intracellular calcium concentrations by reducing voltage-gated calcium channels and prevents the release of neurotransmitters. BQ-123 also has a stabilizing effect on hydrogen bonds due to its charged side chains. This property may account for its ability to form stable complexes with other proteins, inhibiting their function.
BQ-123 has been shown to have an active binding site on cyclic AMP response element binding protein (CREB) that inhibits CREB activity, thereby reducing protein synthesis. It also blocks cyclic GMP (cGMP)-dependent protein kin

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 610.70 g/mol
• Fórmula: C₃₁H₄₂N₆O₇
• Pureza: Min. 95%