Big-Endothelin-3 (Rat, 1-41 Amide)

Ref. 3D-PED-4267-S

Informação sobre produto

• Nome: Big-Endothelin-3 (Rat, 1-41 Amide)
• Sinónimos: Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-Ile-Asn-Thr-Pro-Glu-Gln-Thr-Val-Pro-Tyr-Gly-Leu- Ser-Asn-His-Arg-Gly-Ser-Leu-Arg-NH2
• Marca: Biosynth
• Descrição: Big Endothelin-3 (Rat, 1-41 Amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide, that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11 and is available as a 0.1mg vial.

Propriedades químicas

• Peso molecular: 4,863.5 g/mol
• Fórmula: C₂₁₇H₃₂₂N₅₈O₆₂S₄
• Pureza: Min. 95%