1-[4-[6-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]pyridin-2-yl]piperidin-4-ol

CAS: 1196546-33-4

Ref. 3D-WXB54633

Informação sobre produto

• Nome: 1-[4-[6-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]pyridin-2-yl]piperidin-4-ol

Descrição

(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-amine is an inhibitor of the ion channels TRPC (transient receptor potential cation channel) and TRPV (transient receptor potential vanilloid). It inhibits the TRPC4 ion channel with an IC50 value of 0.7 μM.
TRPV1 is a member of the transient receptor potential (TRP) superfamily, which are nonselective cation channels that play a role in sensation such as pain, temperature, and osmotic changes. It has been shown to inhibit TRPV1 with an IC50 value of 0.7 μM.
Inhibitors of TRPC4 can be used for the treatment of diseases such as chronic pain and neuropathic pain.

• Marca: Biosynth

Propriedades químicas

• Peso molecular: 535.6 g/mol
• Fórmula: C₃₁H₃₀FN₇O
• Pureza: Min. 95%