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Sodium valproate

Sodium valproate

<p>Stability Hygroscopic<br>Applications Antiepileptic; increases levels of GABA in the brain.<br>References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979), Nau, H., et al.: Pharmacol. Toxicol., 69, 310 (1991), Loscher, W., et al.: Prog. Neurobiol., 58, 31 (1999)<br></p>

<p>Sodium valproate is an anticonvulsant drug that has been used to treat bipolar disorder, epilepsy, and migraine headaches. It is a salt of valproic acid and sodium, with a molecular weight of 266.7. Sodium valproate is available in the form of capsules or tablets that are taken orally. This drug has been shown to have interactions with other drugs such as antibiotics, painkillers, and cholesterol-lowering medicines. Side effects include hypersensitivity syndrome, which may be due to an allergic reaction. Sodium valproate has also been linked to the development of blood clots in veins (thrombosis) and decreased white blood cells (leukopenia).<br>The side-effect profiles of sodium valproate are determined by the pharmacological treatment and dosage level in clinical trials. The efficacy of sodium valproate can be assessed by its ability to reduce seizure frequency or severity in patients with epilepsy when titrated calorimetry is used as the</p>

SODIUM VALPROATE CRS

Valproic acid sodium salt

Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.