86-MM3780.01-0025 - d-glucose-pentaacetate | 604-69-3

<p>-D-Glucose Pentaacetate is used in biochemical reaction and also used as an active pharmaceutical intermediate. Further, it is used to stimulate insulin release in rat pancreatic islets. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some docu</p>

β-D-(+)-Glucose pentaacetate

β-D-Glucose pentaacetate

β-D-Glucose pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is a natural product.

<p>Applications D-Glucose pentaacetate was reported to stimulate insulin release in rat pancreatic islets. Only α-D-glucose pentaacetate caused an immediate increase in insulin output. The β-anomer of D-glucose pentaacetate first transiently inhibited insulin release, this initial effect being followed by a secondary rise in secretory rate.<br>References Carpinelli, A., et al.: Mol. Cell Endocrinol., 17, 103 (1980), Hellman, B., et al.: Diab. Metab., 20, 123 (1994), Malaisse, W., et al.: Int. J. Mol. Med., 2, 331 (1998), Sener, A., et al.: Mol. Gen. Metab., 64, 135 (1998),<br></p>

<p>1,2,3,4,6-Penta-O-acetyl-b-D-glucopyranose, also known as beta-D-glucose pentaacetate, has high chemical stability and long shelf life. This protected form of glucose is a key building block of any chemical synthesis of glucose-containing oligosaccharides or glycoconjugates. In the presence of Lewis acids it can be used as a glycosyl donor to make simple glycosides. In order to perform more complex glycosylations, it can be converted into more reactive donors, such as glycosyl halides or thioglycosides. Beta-D-glucose pentaacetate is also used as a food additive and flavouring agent.</p>