86-MM3915.00-0250 - psoralen | 66-97-7

Psoralen analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Lactones nesoi

Psoralen

Psoralen

Psoralen crosslinking between human immunodeficiency virus type 1 RNA and primer tRNA3(Lys).

<p>Psoralen (Ficusin) is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.</p>

Lactone

<p>Applications Psoralens are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems.<br>References Parsons, B.J., et al.: Photochem. Photobiol., 32, 813 (1980),<br></p>

<p>Psoralen is a naturally occurring furocoumarin compound, which is derived from various plants, including those in the Apiaceae family, such as parsley and celery. Its mode of action involves intercalating into DNA and forming covalent cross-links when activated by ultraviolet A (UVA) light. This photoreactivity enables it to modify the biological activity of nucleic acids, making it a valuable tool in both therapeutic and experimental settings.</p>

<p>Intercalates into DNA; photochemical reagent for the investigation of nucleic acid structure</p>