AC-12816 - naphthoflavone-97 | 604-59-1

<p>An aryl hydrocarbon receptor antagonist This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a pa</p>

7,8-Benzoflavone analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

α-Naphthoflavone

α-Naphthoflavone

<p>alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.</p>

7,8-Benzoflavone is a synthetic flavonoid compound, which is derived from the structural modification of naturally occurring flavones. It possesses significant biochemical activity attributed to its ability to act as a potent inhibitor of certain cytochrome P450 enzymes, particularly CYP1A1 and CYP1B1. By inhibiting these enzymes, 7,8-Benzoflavone modulates the metabolism of various xenobiotics, impacting the bioactivation or detoxification of potential carcinogens.

<p>Alpha-naphthoflavone is a synthetic flavonoid, which is an aryl hydrocarbon receptor antagonist known for its interaction with cytochrome P450 enzymes. It is typically synthesized in laboratory settings and does not occur naturally. Alpha-naphthoflavone acts by competitively inhibiting the binding of ligands to the aryl hydrocarbon receptor (AhR) and modulating the activity of cytochrome P450 enzymes, particularly CYP1A1 and CYP1B1. This modulation is crucial in studying the metabolic pathways and the mechanism of enzyme induction or inhibition in xenobiotic metabolism.</p>