AC-17227 - 2-2-2-chloroethoxyethoxyethanol-95 | 5197-62-6

KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.

Applications Dibenzazepine (Deshydroxy LY 411575) is a dipeptidic γ-secretase inhibitor and anti-Alzheimer agent (1,2,3,4).
References (1) Weihofen, A., et al.: Science, 296, 2215 (2002) (2) Weihofen, A., et al.: J. Biol. Chem., 278, 16528 (2003) (3) Kan, T., et al.: Bioorg. Med. Chem. Lett., 14, 1983 (2004) (4) Krawitz, P., et al.: J. Biol. Chem., 280, 39515 (2005)

Applications (+)-Fenchone is a terpenoid with broad spectrum activity against infective agents. It is a constituent of the essential oil component of fennel fruit. Fenchone is widely used as a flavouring agent in food industries, and also for perfumery in cosmetics industries.
References Mafud, A. C., et al.: Chem. Biol. Interact., 244, 129 (2016); Kan, Y., et al.: Ankara Universitesi Eczacilik Fakultesi Dergisi, 35, 95 (2006); Kpoviessi, S., et al.; J. Ethnopharmacol., 151, 652 (2014)

Impurity Ketoconazole EP Impurity C
Applications rac-trans-Ketoconazole (Ketoconazole EP Impurity C) is a Ketoconazole (K186000) analog. The trans isomer of Ketoconazole.
References Kan, P.B., et al.: J. Steroid Biochem., 23, 1023 (1985),

Applications Trinonanoin is an analog of Tricaproin (T773780) which is used as a delivery system for Paclitaxel (P132500), an anticancer agent.
References Kan, P., et al.: J. Controlled Release, 58, 271 (1999); Yoshizawa, Y., et al.: Int. J. Pharma., 412, 132 (2011)

Palladium(II) sulfate dihydrate is used as a raw material to prepare other palladium complexes. It acts as a catalyst in synthetic chemistry. It is also used in electroplating. In the presence of sulfuric acid, it is used for activation of alkanes. This Thermo Scientific Chemicals brand product was

Nitronium hexafluorophosphate is a nitrating reagent used in the nitration of alkanes such as methane, ethane, propane, n-butane, isobutane, neopentane and cyclohexane. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and labe

Tantalum(V) fluoride is used as a Friedel-Crafts catalyst. It combines with hydrogen fluoride and acts as a catalyst for the alkylation of alkanes and alkenes as well as the protonation of aromatic compounds. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar produc

Nickel(II) chloride is a mild Lewis acid used for the regioselective isomerization of dienols and selective reduction of alkenes to alkanes in presence of Lithium aluminum hydride. It is used as a precursor to nickel boride, finely divided nickel. It acts as a catalyst to prepare dialkyl arylphospho

n-Tetradecane is used to study the thermodiffusion behavior of the microemulsion droplets of water, n-alkanes and pentaethylene glycol monododecyl ether. It is used as reference material in gas chromatographic analysis, as a solvent and finds applications in organic synthesis. This Thermo Scientific

n-Hexatriacontane is used as a paraffin wax and in candles. It is used as a key starting material for the preparation of lower alkanes by cracking. It is also used for example in road surfacing. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. S

Osmium(III) chloride trihydrate is used as a reagent for preparation of dichlorodihydridoosmium complexes. It is also useful as starting materials and an efficient alkane oxidation catalyst in the presence of pyridine and hydrogen oxide. This Thermo Scientific Chemicals brand product was originally

Deuterated DMSO is a common solvent used in NMR spectroscopy. It is in combination with pyridine-d5 plays an important role for solution-state 2D NMR of ball-milled plant cell wall gel. Low-energy collisions of ionized acetone-d6, DMSO-d6 and pyridine-d5 with alkanethiolate is used to prepare self-a