Bardoxolone
CAS: 218600-44-3
Ref. TM-T2915
5mg | 74,00 € | ||
10mg | 90,00 € | ||
25mg | 108,00 € | ||
50mg | 129,00 € | ||
100mg | 230,00 € | ||
1ml*10 (DMSO) | 80,00 € |
Informação sobre produto
- RTA 401, CDDO
- 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid
Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis. In various Y cell lines, Bardoxolone has been shown to specifically inhibit proliferation and induce apoptosis. Mechanism studies revealed that Bardoxolone is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.
Propriedades químicas
Consulta técnica sobre: TM-T2915 Bardoxolone
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