Citrulline-specific Probe-Rhodamine
CAS: 2309313-01-5
Ref. TM-T36104
| 1mg | 1.326,00 € | ||
| 250µg | 419,00 € | ||
| 500µg | 751,00 € |
Informação sobre produto
Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Abnormally high PAD activity has been observed in a host of human diseases. Citrulline-specific probe-rhodamine is a highly sensitive, rhodamine phenylglyoxal-based fluorophore that specifically detects protein citrullination via a chemoselective reaction between glyoxal and citrulline. This chemical probe (comprised of a single isomer) is capable of reacting with any citrulline-containing protein and can be analyzed with fluorescent imaging (excitation 532 nm; emission 580 nm). When added at 100 μM for 30 minutes at acidic pH, this probe has a reported limit of detection of ~10 ng for citrullinated histone H3 and ~1 ng for autodeiminated PAD4.
Propriedades químicas
Consulta técnica sobre: TM-T36104 Citrulline-specific Probe-Rhodamine
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