Informação sobre produto
- (-)-(E)-Guggulsterone
- (17E)-Pregna-4,17(20)-diene-3,16-dione
- (17E)-pregna-4,17-diene-3,16-dione
- 4,17(20)-(trans)-Pregnadiene-3,16-dione
- E-Guggulsteron
- Guggulsterone E
- trans-Guggulsterone
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR bothin vitroandin vivo.4Thecisstereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50value of 15 μM.5,6By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.4
Propriedades químicas
Consulta técnica sobre: TM-T36563 (E)-Guggulsterone
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