Informação sobre produto
- 2-(3,4-Dihydroxyphenyl)acetaldehyde
- 3,4-Dihydroxy-α-tolualdehyde
- 3,4-Dihydroxybenzeneacetaldehyde
- Acetaldehyde, (3,4-dihydroxyphenyl)-
- Benzeneacetaldehyde, 3,4-Dihydroxy-
- Dopal
- Homoprotocatechualdehyde
DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.[4]
Propriedades químicas
Consulta técnica sobre: TM-T37533 DOPAL
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