(±)-Praeruptorin A

CAS: 73069-25-7

Ref. TM-T4S1419

Informação sobre produto

• Nome: (±)-Praeruptorin A
• Sinónimos: Praeruptorin A, (-)-Praeruptorin A, (-)-Pareruptorin A, Ccris 7247, (9R,10R)-10-(acetyloxy)-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-9-yl (2Z)-2-methylbut-2-enoate
• CAS: 73069-25-7

Descrição

1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.

• Marca: Targetmol

Propriedades químicas

• Peso molecular: 386.4
• Fórmula: C₂₁H₂₂O₇
• Pureza: 99.73%
• Cor/forma: Solid