(±)5(6)-DiHET

CAS: 213382-49-1

Ref. TM-T84609

Informação sobre produto

• Nome: (±)5(6)-DiHET
• Sinónimos: (±)5,6-DiHETrE, (+/-)5,6-DiHETrE, (8Z,11Z,14Z)-5,6-Dihydroxy-8,11,14-eicosatrienoic acid, (±)-5,6-Dihydroxy-8Z,11Z,14Z-eicosatrienoic acid, 213382-49-1, 5,6-Dhet, 5,6-Dihydroxyeicosatrienoic acid, 8,11,14-Eicosatrienoic acid, 5,6-dihydroxy-, (8Z,11Z,14Z)-
• CAS: 213382-49-1

Descrição

5(6)-DiHET is a racemic compound synthesized through the action of epoxide hydrolases on 5(6)-EET, encompassing both enantiomeric forms. It serves as a quantitative marker for 5(6)-EET, facilitating its measurement by utilizing the compound's conversion to 5(6)-δ-lactone in solution. Additionally, 5(6)-DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in rat small coronary artery smooth muscle cells, supporting its biological significance in vascular regulation. It also acts as a substrate for sheep seminal vesicle COX, leading to the in vitro production of 5,6-dihydroxy prostaglandin E1 and F1α metabolites. Notably, its levels diminish in the plasma of rats subjected to a high-fat diet, indicating a potential role in the pathophysiology of hyperlipidemia.

• Marca: Targetmol