BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)
Ref. TM-TMPH-02536
| 20µg | 1.655,00 € | ||
| 100µg | 2.861,00 € |
Informação sobre produto
- Bnip3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, Nip3
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Propriedades químicas
Consulta técnica sobre: TM-TMPH-02536 BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)
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