ACOD1 Protein, Mouse, Recombinant (His & Myc)
Ref. TM-TMPH-02585
| 1mg | 2.841,00 € | ||
| 20µg | 496,00 € | ||
| 100µg | 1.354,00 € |
Informação sobre produto
- Cis-aconitate decarboxylase, Cis-aconitic acid decarboxylase, Aconitate decarboxylase, Aconitate decarboxylase 1, IRG1, Immune-responsive gene 1 protein, CAD
Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.
Propriedades químicas
Consulta técnica sobre: TM-TMPH-02585 ACOD1 Protein, Mouse, Recombinant (His & Myc)
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