TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)

Ref. TM-TMPK-00277

Informação sobre produto

• Nome: TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)
• Sinónimos: TRAIL R2, TNFRSF10B, TRICK2, KILLER, DR5, TRAIL receptor 2, Fas-like protein, TRICKB, ZTNFR9, DR5TRICK2B, CD262, TRICK2A, KILLER/DR5, TRAILR2

Descrição

DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

• Marca: Targetmol

Propriedades químicas

• Peso molecular: 41.1 kDa (predicted). Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result.
• Cor/forma: Solid