Informação sobre produto
Nome:NT5C3A/NT5C3 Protein, Human, Recombinant
Sinónimos:
- UMPH1
- UMPH
- PSN1
- POMP
- PN-I
- P5N-1
- P5'N-1
- P5N1
- p36
- NT5C3
- hUMP1
- cN-III
- Ver mais sinónimos
Marca:Targetmol
Descrição:NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but not of its catalytic mutants, suppressed IL-8 production by HEK293 cells. NT5C3A-stimulated sirtuin activity resulted in deacetylation of histone H3 and the NF-kappaB subunit RelA (also known as p65), both of which were associated with the proximal region of the Il8 promoter, thus repressing the transcription of Il8 Together.
Aviso:Os nossos productos estão destinados exclusivamente para uso em laboratório. Para qualquer outra aplicação, por favor entre em contacto.
Propriedades químicas
Peso molecular:32.7kDa (predicted); 32 kDa (reducing conditions)
Cor/forma:Liquid