Serpentine

CAS: 18786-24-8

Ref. TM-TN4997

Informação sobre produto

• Nome: Serpentine
• Sinónimos: (19 alpha)-3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19-methyloxayohimbanium, (19Alpha)-16-(Methoxycarbonyl)-19-Methyl-3,4,5,6,16,17-Hexadehydro-18-Oxayohimban-4-Ium, (19α)-3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19-methyloxayohimbanium, 3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19alpha-methyl-18-oxayohimbanium (inneres salz), 3,4,5,6-Tetradehydroajmalicine, Indolo[2,3-a]pyrano[3,4-g]quinolizin-6-ium, oxayohimbanium deriv., Methyl (19Alpha)-19-Methyl-1,3,5,6,16,17-Hexadehydro-18-Oxayohimban-16-Carboxylate, Methyl 19-Methyl-3,4,5,6,16,17-Hexadehydro-18-Oxayohimban-4-Ium-16-Carboxylate, Nsc 407301, Oxayohimbanium, 3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, (19alpha)-, Oxayohimbanium, 3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, (19α)-, Serpentine (VAN)
• CAS: 18786-24-8

Descrição

Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose uptake by C2C12 cells.Serpentine increases the expression of GSK-3β mRNA in muscle tissues, which enhances glucose uptake.Serpentine also increases glucose production and hepatic gluconeogenesis.Serpentine has a significant effect on glucagon secretion and hepatic gluconeogenesis. Serpentine significantly increased glucagon secretion and hepatic gluconeogenesis. In high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice, Serpentine significantly prolonged insulin hypoglycemia, significantly decreased exogenous insulin use, and inhibited endogenous insulin secretion.

• Marca: Targetmol

Propriedades químicas

• Peso molecular: 349.4
• Fórmula: C₂₁H₂₁N₂O₃
• Pureza: 98%
• Cor/forma: Solid