1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone

CAS: 1801881-15-1

Ref. TR-A180180

Informação sobre produto

• Nome: 1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone
• Sinónimos: 1-(4-aminophenyl)-5-chloro-2,3-dihydropyridin-6-one

Descrição

Applications 1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone is an impurity of Apixaban (A726700(P)), which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. Apixaban is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References Luettgen, J. M., et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T., et al.: J. Thromb. Thrombol., 31, 310 (2011); Barrett, Y. C., et al.: Thromb. Haemos., 105, 181 (2011);

• Marca: TRC

Propriedades químicas

• Peso molecular: 222.671
• Fórmula: C₁₁H₁₁ClN₂O
• Cor/forma: Neat
• InChI: InChI=1S/C11H11ClN2O/c12-10-2-1-7-14(11(10)15)9-5-3-8(13)4-6-9/h2-6H,1,7,13H2
• Chave InChI: InChIKey=HVHHXVHBWVUZAP-UHFFFAOYSA-N
• SMILES: Nc1ccc(N2CCC=C(Cl)C2=O)cc1