(-)-Actinonin

CAS: 13434-13-4

Ref. TR-A192000

Informação sobre produto

• Nome: (-)-Actinonin
• Sinónimos: N'-hydroxy-N-[1-[2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide, (2R)-N⁴-Hydroxy-N¹-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide, (2R)-N~4~-hydroxy-N~1~-{(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide, 3-[[1-[[2-(Hydroxymethyl)-1-Pyrrolidinyl]-Carbonyl]-2-Methylpropyl]-Carbamoyl]-Octonohydroxamic Acid, 3-[[1-[[2-(Hydroxymethyl)-1-Pyrrolidinyl]Carbonyl]-2-Methyl-Propyl]Carbamoyl]Octanohydroxamic Acid, Actinonine, Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, (2R)-, Butanediamide, N⁴-hydroxy-N¹-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, stereoisomer, Cona 57, Hylpropyl)Carbamoyl)-, N4-Hydroxy-N1-[(1S)-1[[(2S)-2-(hydroxymethyl)-1-pyrroldinyl]carbonyl]-2-methylpropyl]-2-pentyl-,(2R)-(9CI), N~4~-hydroxy-N~1~-{1-[2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide, Octanohydroxamic acid, 3-[[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]-, Octanohydroxamicacid,3-((1-((2-(Hydroxymethyl)-1-Pyrrolidinyl)Carbonyl)-2-Met, Ro 06-1467

Descrição

Applications (-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell invasion and matrix degradation along with displayed antitumor activity in vitro and in vivo as well as acting as an apoptotic inducer.
References Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985), Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009), Berg, A., et al.: Biochem., 48, 1584 (2009), Kuehlmann, U., et al.: Life Sci., 84, 1 (2009),

• Marca: TRC

Propriedades químicas

• Peso molecular: 385.50
• Fórmula: C₁₉H₃₅N₃O₅
• Cor/forma: Neat
• InChI: InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
• Chave InChI: InChIKey=XJLATMLVMSFZBN-ZOBUZTSGSA-N
• SMILES: CCCCC[C@@H](CC(=O)NO)C(=O)N[C@H](C(=O)N1CCC[C@H]1CO)C(C)C