(3alpha)-Allopregnanolone

CAS: 516-54-1

Ref. TR-A547100

Informação sobre produto

• Nome: (3alpha)-Allopregnanolone
• Sinónimos: ALLO, Brexanolone, 3a,5a-tetrahydro Progesterone, 3a,5a-THP, (3a,5a)-3-hydroxy-pregnan-20-one, (+)-3α-Hydroxy-5α-pregnan-20-one, (3α)-Allopregnanolone, (3α,5α)-3-Hydroxypregnan-20-one, 3α,5α-Pregnanolone, 3α,5α-THP, 3α,5α-Tetrahydroprogesterone, 3α-Hydroxy-5α-dihydroprogesterone, 3α-Hydroxy-5α-pregnane-20-one, 5α-Pregnan-20-one, 3α-hydroxy-, 5α-Pregnan-3α-ol-20-one, 5α-Pregnane-3α-ol-20-one, Allopregnan-3α-ol-20-one, Allopregnanolone, Allopregnanolone (SAGE-547), Allotetrahydroprogesterone, Pregnan-20-one, 3-hydroxy-, (3α,5α)-, Sage 547, Zulresso
• CAS: 516-54-1

Descrição

Applications (3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain. In 2019, the US Food and Drug Administration approved (3α)-Allopregnanolone as an intravenous infusion for treating postpartum depression.
References Puja, G. et al.: Neuron, 4, 759 (1990); Belelli, D. et ael. Neurosteroid, 6, 565 (2006); Viapiano, M. et al.: Neurochem. Res., 23, 155 (1998);

• Marca: TRC

Propriedades químicas

• Peso molecular: 318.49
• Fórmula: C₂₁H₃₄O₂
• Cor/forma: Neat
• InChI: InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
• Chave InChI: InChIKey=AURFZBICLPNKBZ-SYBPFIFISA-N
• SMILES: CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C