17-(Allylamino-d5) Geldanamycin

CAS: 75747-14-7

Ref. TR-A549652

Informação sobre produto

• Nome: 17-(Allylamino-d5) Geldanamycin
• Sinónimos: 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin, 17-(Allylamino-d5)-17-demethoxygeldanamycin, 17-(Allylamino-d5)-17-desmethylgeldanamycin, 17-Demethoxy-17-(allylamino-d5)geldanamycin, 17AAG-d5, CP 127374-d5, KOS 953-d5, NSC 330507-d5, Tanespimycin-d5, (4Z,6E,10E)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, (8R,9R,12R,13S,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, (8S,9S,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, 17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)-17-desmethylgeldanamycin, 17-(Allylamino)geldanamycin, 17-Allylaminodemethoxygeldanamycin, 17-Allylaminogeldanamycin, 17-Demethoxy-17-(2-propenylamino)geldanamycin, 17-Demethoxy-17-allylaminogeldanamycin, 17-N-Allylamino-17-demethoxygeldanamycin, 17Aag, 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv., A 8476, Bms 722782, Cp 127374, Geldanamycin, 17-demethoxy-17-(2-propenylamino)-, Kos 953, NSC 330507, Tanespimycin

Descrição

Applications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),

• Marca: TRC

Propriedades químicas

• Peso molecular: 590.719
• Fórmula: C₃₁D₅H₃₈N₃O₈
• Cor/forma: Neat
• InChI: InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1/i1D2,8D,12D2
• Chave InChI: InChIKey=AYUNIORJHRXIBJ-RDXCHMSBSA-N
• SMILES: [2H]C([2H])=C([2H])C([2H])([2H])NC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O