2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester

CAS: 6966-01-4

Ref. TR-A601863

Informação sobre produto

• Nome: 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester
• Sinónimos: 2-Pyrazinecarboxylic acid, 3-amino-6-bromo-, methyl ester, Pyrazinecarboxylic acid, 3-amino-6-bromo-, methyl ester (9CI), 3-Amino-6-bromo-2-pyrazinecarboxylic acid methyl ester, Methyl 3-amino-6-bromopyrazine-2-carboxylate, NSC 18700
• Marca: TRC
• Descrição: Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)

Propriedades químicas

• Peso molecular: 232.03
• Fórmula: C₆H₆BrN₃O₂
• Cor/forma: Neat
• InChI: InChI=1S/C6H6BrN3O2/c1-12-6(11)4-5(8)9-2-3(7)10-4/h2H,1H3,(H2,8,9)
• Chave InChI: InChIKey=CNXSIRHOIFRMOB-UHFFFAOYSA-N
• SMILES: COC(=O)c1nc(Br)cnc1N