5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-Dihydroxybutanedioate

CAS: 239463-85-5

Ref. TR-A628255

Informação sobre produto

• Nome: 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-Dihydroxybutanedioate
• Sinónimos: 1H-Indole-7-carbonitrile, 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) (9CI, ACI), 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile tartrate, 3-[5-[(2R)-Aminopropyl]-7-cyano-2,3-dihydro-1H-indol-1-yl]propyl benzoate (2R,3R)-monotartarate
• Marca: TRC
• Descrição: Applications 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-Dihydroxybutanedioate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.References Wang, X., et al.: A process for the preparation of silodosin, Indian Patent 2013CH03274, Jan 30, 2015

Propriedades químicas

• Peso molecular: 513.54
• Fórmula: C₂₆H₃₁N₃O₈
• Cor/forma: Neat
• InChI: InChI=1S/C22H25N3O2.C4H6O6/c1-16(24)12-17-13-19-8-10-25(21(19)20(14-17)15-23)9-5-11-27-22(26)18-6-3-2-4-7-18;5-1(3(7)8)2(6)4(9)10/h2-4,6-7,13-14,16H,5,8-12,24H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t16-;1-,2-/m11/s1
• SMILES: C[C@H](N)Cc1cc(C#N)c2c(c1)CCN2CCCOC(=O)c1ccccc1.O=C(O)[C@H](O)[C@@H](O)C(=O)O