2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone

CAS: 870281-86-0

Ref. TR-A628755

Informação sobre produto

• Nome: 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone
• Sinónimos: 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone, (S)-1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propan-1-amine, (S)-2-(1-Aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenylquinazolin-4-one, 4(3H)-Quinazolinone, 2-[(1S)-1-aminopropyl]-5-fluoro-3-phenyl-
• CAS: 870281-86-0

Descrição

Applications 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone is used as reagent/reactant in synthetic preparation of idelalisib using the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline as the key step.
References Liu, J., et al.: Org. Prep. Proced. Int., 48, 337-341 (2016);

• Marca: TRC

Propriedades químicas

• Peso molecular: 297.33
• Fórmula: C₁₇H₁₆FN₃O
• Cor/forma: Neat
• InChI: InChI=1S/C17H16FN3O/c1-2-13(19)16-20-14-10-6-9-12(18)15(14)17(22)21(16)11-7-4-3-5-8-11/h3-10,13H,2,19H2,1H3/t13-/m0/s1
• Chave InChI: InChIKey=BNMGOWXQUZHWIO-ZDUSSCGKSA-N
• SMILES: CC[C@H](N)c1nc2cccc(F)c2c(=O)n1-c1ccccc1