1-[(3-Amino-4-quinolinyl)amino]-2-methyl-2-propanol

CAS: 129655-59-0

Ref. TR-A629168

Informação sobre produto

• Nome: 1-[(3-Amino-4-quinolinyl)amino]-2-methyl-2-propanol
• Sinónimos: 1-[(3-Aminoquinolin-4-yl)amino]-2-methylpropan-2-ol, 3-Amino-4-(2-hydroxy-2-methylpropylamino)quinoline

Descrição

Applications 1-[(3-Amino-4-quinolinyl)amino]-2-methyl-2-propanol is an intermediate in synthesizing Resiquimod-d5 (R144682), an isotope labelled Resiquimod (R144680) which is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.
References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008)

• Marca: TRC

Propriedades químicas

• Peso molecular: 231.29
• Fórmula: C₁₃H₁₇N₃O
• Cor/forma: Neat
• InChI: InChI=1S/C13H17N3O/c1-13(2,17)8-16-12-9-5-3-4-6-11(9)15-7-10(12)14/h3-7,17H,8,14H2,1-2H3,(H,15,16)
• Chave InChI: InChIKey=LHBODUUXCWHZLN-UHFFFAOYSA-N
• SMILES: CC(C)(O)CNc1c(N)cnc2ccccc12