Apixaban Dimer

CAS: 1998079-11-0

Ref. TR-A726725

Informação sobre produto

• Nome: Apixaban Dimer
• Sinónimos: R 2988

Descrição

Applications Apixaban Dimer is an impurity compound of Apixaban (A726700). Apixaban is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful in the prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References Luettgen, J. M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);

• Marca: TRC

Propriedades químicas

• Peso molecular: 750.78
• Fórmula: C₄₀H₃₄N₁₀O₆
• Cor/forma: Neat
• InChI: InChI=1S/C40H34N10O6/c1-55-29-15-11-27(12-16-29)49-35-31(33(45-49)37(41)51)19-21-47(39(35)53)25-7-3-23(4-8-25)43-44-24-5-9-26(10-6-24)48-22-20-32-34(38(42)52)46-50(36(32)40(48)54)28-13-17-30(56-2)18-14-28/h3-18H,19-22H2,1-2H3,(H2,41,51)(H2,42,52)/b44-43+
• Chave InChI: InChIKey=AVTTWDVUNBNBBR-VGFSZAGXSA-N
• SMILES: COc1ccc(-n2nc(C(N)=O)c3c2C(=O)N(c2ccc(/N=N/c4ccc(N5CCc6c(C(N)=O)nn(-c7ccc(OC)cc7)c6C5=O)cc4)cc2)CC3)cc1