(1R)-Benazepril tert-Butyl Ester

CAS: 1356841-36-5

Ref. TR-B119855

Informação sobre produto

• Nome: (1R)-Benazepril tert-Butyl Ester
• Sinónimos: (3S)-3-[[(1R)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid 1,1-Dimethylethyl Ester, [R-(R*,R*)]-3-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic Acid 1,1-Dimethylethyl Ester

Descrição

Applications R-Benazepril tert-Butyl Ester is an isomer of Benazepril tert-Butyl Ester (B119850) which is a useful synthetic intermediate in the synthesis of Benazepril Hydrochloride (B119750), a potent angiotensin converting enzyme (ACE) inhibitor and antihypertensive.
References Kafssi, H., et al.: Huaxue Shiji, 29, 371 (2007); Chang, C.Y., et al.: Tetrahedron-Assymetr., 14, 2239 (2003); Schaller, M.D., et al.: Eur. J. Clin. Pharmacol., 28, 267 (1985); Colfer, H.T., et al.: Am. J. Cardiol., 70, 354 (1992)

• Marca: TRC

Propriedades químicas

• Peso molecular: 480.596
• Fórmula: C₂₈H₃₆N₂O₅
• Cor/forma: Neat
• InChI: InChI=1S/C28H36N2O5/c1-5-34-27(33)23(17-15-20-11-7-6-8-12-20)29-22-18-16-21-13-9-10-14-24(21)30(26(22)32)19-25(31)35-28(2,3)4/h6-14,22-23,29H,5,15-19H2,1-4H3/t22-,23+/m0/s1
• Chave InChI: InChIKey=QNLLWVSHZXSUNF-XZOQPEGZSA-N
• SMILES: CCOC(=O)[C@@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)OC(C)(C)C)C1=O