Bisindolylmaleimide VIII Acetic Acid Salt

CAS: 138516-31-1

Ref. TR-B448500

Informação sobre produto

• Nome: Bisindolylmaleimide VIII Acetic Acid Salt
• Sinónimos: 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Acetic Acid Salt, Ro 31-7549 Acetic Acid Salt, Ro 31-7549/001 Acetic Acid Salt, 1H-pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1)
• CAS: 138516-31-1

Descrição

Applications It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.
References Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998), Wiley, S., et al.: Immunity, 3, 673 (1995), MacFarlane, M., et al.: Biochem. J., 348, 93 (2000),

• Marca: TRC

Propriedades químicas

• Peso molecular: 458.51
• Fórmula: C₂₆H₂₆N₄O₄
• Cor/forma: Neat
• InChI: InChI=1S/C24H22N4O2.C2H4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20;1-2(3)4/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30);1H3,(H,3,4)
• Chave InChI: InChIKey=VEOXVBTXROWDAH-UHFFFAOYSA-N
• SMILES: CC(=O)O.Cn1cc(C2=C(c3cn(CCCN)c4ccccc34)C(=O)NC2=O)c2ccccc21