(S)-tert-Butyl (2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate

CAS: 1448440-50-3

Ref. TR-B503840

Informação sobre produto

• Nome: (S)-tert-Butyl (2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate
• Sinónimos: tert-butyl N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamate

Descrição

Applications (S)-tert-Butyl (2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate is a reagent in the synthesis of (S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide (UAMC1110) (S687910) which is a useful research chemical and a fibroblast activation protein inhibitor displaying low nanomolar inhibitory potency and high selectivity against related dipeptidyl peptidases.
References De D., et al.: ACS Med. Chem., 10, 1173 (2019); Simon, P., et al.: ACS Chem. Biol., 13, 3333 (2018); De D., et al.: ACS Med. Chem. Lett., 10, 1173 (2019)

• Marca: TRC

Propriedades químicas

• Peso molecular: 289.279
• Fórmula: C₁₂H₁₇F₂N₃O₃
• Cor/forma: Neat
• InChI: InChI=1S/C12H17F2N3O3/c1-11(2,3)20-10(19)16-6-9(18)17-7-12(13,14)4-8(17)5-15/h8H,4,6-7H2,1-3H3,(H,16,19)/t8-/m0/s1
• SMILES: CC(C)(C)OC(=O)NCC(=O)N1CC(F)(F)C[C@H]1C#N