5-Bromoisoindoline Hydrochloride

CAS: 919346-89-7

Ref. TR-B678895

Informação sobre produto

• Nome: 5-Bromoisoindoline Hydrochloride
• Sinónimos: 5-Bromo-2,3-dihydro-1H-isoindole Hydrochloride

Descrição

Applications 5-Bromoisoindoline Hydrochloride acts as a reagent in the preparation of cyanopyrrolidines as DUB inhibitors for the treatment of cancer, preparation of oxazolidinone containing fused ring as antibiotics, preparation of novel indolecarboxamides as IKK2 inhibitors. Also a derivative salt of 5-Bromoisoindoline Hydrochloride (B683270), which is an intermediate used in the synthesis of 2,3-dihydro-1H-isoindoles with high affinity and selectivity for dopamine D3 receptor.
References Austin, N., et al.: Bioorg. Med. Chem. Lett., 11, 685 (2001); Kemp, M., et al.: PCT Int. Appl. (2017), WO 2017009650 A1 20170119; Zhang, H., et al.: PCT Int. Appl. (2013), WO 2013044865 A1 20130404; Deng, J., et al.: U.S. Pat. Appl. Publ. (2009), US 20090143372 A1 20090604

• Marca: TRC

Propriedades químicas

• Peso molecular: 198.063646
• Fórmula: C₈H₈BrN•hCi
• Cor/forma: Neat
• InChI: InChI=1S/C8H8BrN.ClH/c9-8-2-1-6-4-10-5-7(6)3-8;/h1-3,10H,4-5H2;1H
• Chave InChI: InChIKey=GDMXNYRWVLBUDZ-UHFFFAOYSA-N
• SMILES: Brc1ccc2c(c1)CNC2.Cl