2,3-Bis((tert-Butyldimethylsilyl)oxy)-2-hydroxy Estrone 6-N3-Adenine

Ref. TR-B942743

Informação sobre produto

• Nome: 2,3-Bis((tert-Butyldimethylsilyl)oxy)-2-hydroxy Estrone 6-N3-Adenine

Descrição

Applications 2,3-Bis((tert-Butyldimethylsilyl)oxy)-2-hydroxy Estrone 6-N3-Adenine is an intermediate in the synthesis of 4-Hydroxy Estradiol 1-N3-Adenine which is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. The N3Ade depurinating adducts could serve as biomarkers to predict the risk of breast cancer.
References Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000), Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000), Chakravarti, D., et al.: Oncogene, 20, 7945 (2001), Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2002),

• Marca: TRC

Propriedades químicas

• Peso molecular: 648
• Fórmula: C₃₅H₅₃N₅O₃Si₂
• Cor/forma: Light Brown
• InChI: InChI=1S/C35H53N5O3Si2/c1-33(2,3)44(8,9)42-27-17-22-21-14-15-35(7)25(12-13-29(35)41)23(21)16-26(40-20-39-31(36)30-32(40)38-19-37-30)24(22)18-28(27)43-45(10,11)34(4,5)6/h17-21,23,25-26H,12-16,36H2,1-11H3/t21-,23-,25+,26?,35+/m1/s1
• Chave InChI: InChIKey=GXANMBISFKBPEX-ARJAWSKDSA-N
• SMILES: CC/C=C\CC=O