5-​[[[(2,​4-​Difluorophenyl)​methyl]​amino]​carbonyl]​-​1,​4-​dihydro-​3-​methoxy-​4-​oxo-​1-​(2-​oxoethyl)​-2-​pyridinecarboxylic Acid Methyl Ester

CAS: 1646862-09-0

Ref. TR-C164685

Informação sobre produto

• Nome: 5-​[[[(2,​4-​Difluorophenyl)​methyl]​amino]​carbonyl]​-​1,​4-​dihydro-​3-​methoxy-​4-​oxo-​1-​(2-​oxoethyl)​-2-​pyridinecarboxylic Acid Methyl Ester
• Sinónimos: Methyl 5-((2,4-Difluorobenzyl)carbamoyl)-3-methoxy-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-2-carboxylate

Descrição

Applications 5-​[[[(2,​4-​Difluorophenyl)​methyl]​amino]​carbonyl]​-​1,​4-​dihydro-​3-​methoxy-​4-​oxo-​1-​(2-​oxoethyl)​-2-​pyridinecarboxylic Acid Methyl Ester is an intermediate in the synthesis of Cabotegravir-d3 (C050102), which is the labelled form of Cabotegravir (C050100). Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.
References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)

• Marca: TRC

Propriedades químicas

• Peso molecular: 394.33
• Fórmula: C₁₈H₁₆F₂N₂O₆
• Cor/forma: Yellow Solid
• InChI: InChI=1S/C18H16F2N2O6/c1-27-16-14(18(26)28-2)22(5-6-23)9-12(15(16)24)17(25)21-8-10-3-4-11(19)7-13(10)20/h3-4,6-7,9H,5,8H2,1-2H3,(H,21,25)
• Chave InChI: InChIKey=WWHLFKYABPHRSQ-UHFFFAOYSA-N
• SMILES: COC(=O)c1c(OC)c(=O)c(C(=O)NCc2ccc(F)cc2F)cn1CC=O